MyBioSource.com's USP6 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The USP6 Antibody was generated using USP6 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Function: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Subunit Structure: Interacts with RAC1 and CDC42. Interacts (via Rab-GAP TBC domain) with ARF6. Interacts with calmodulin (CALM1, CALM2 and/or CALM3); the interaction is calcium-dependent.
Post-translational Modifications: Monubiquitinated; ubiquitination is calmodulin and calcium dependent.
Similarity: The Rab-GAP TBC domain lacks GTPase activator activity but is necessary for interaction with ARF6. Belongs to the peptidase C19 family